9007-28-7

Product Details:

CasNo： 9007-28-7

Molecular Formula： C13H21NO15S

Appearance： White to Off-White Powder

Delivery Time： 2 weeks after order

Throughput： 100KG/Month

Purity： 99%

Synonyms: poly-1(2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6)sulfonyl-d-galactose; chondroitinpoly sulfate; chondroitin sulfates; chondroitin sulfuric acid; chondroitin sulfuric acids; chonsurid; CSO; (5ξ)-2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulf o-α-L-arabino-hexopyranose
Water Solubility: Soluble in water

Uses: 
Chondroitin sulfate is used in a wide variety of areas of research such as bioengineering. It may be used as a biomaterial copolymer or surface derivatization reagent in the development of drug delivery vehicles, tissue engineering devices and bioscaffolds. Chondroitin sulfate may be used for the development of biocompatible structures such as hydrogels, sponges, biofilms, microspheres and micelles. Used in the treatment of coronary atherosclerosis, myocardial ischemia, myocardial infraction.

General Description:
Chondroitin sulfate is a mixture of acid mucopolysaccharides extracted from the cartilage of pigs, cattle, chicken, and shark cartilage. According to their differences in chemical composition and structure, it is divided into A, B, C, D, E, F, H, etc. It mainly contains mucopolysaccharides such as chondroitin sulfate A and chondroitin sulfate C. Both chondroitin sulfate A and C contain D-glucuronic acid and 2-hydroperoxy group-deoxy-D-galactose, and contain equal amounts of acetyl and sulfuric acid residue. The only difference between them is the different position of sulfuric acid ester on the hexosamine residues. Chondroitin sulfate A can enhance the activity of lipase, causing the decomposition of triglyceride in chylomicron so that the blood will become clean due to the decrease of chylomicrons. It has anticoagulant and antithrombotic effect, and thus is clinically used for the treatment of coronary artery disease, elevated blood lipids and cholesterol, angina, neuralgia, myocardial ischemia and myocardial infarction embolism. It can also be used for prevention and treatment of hearing disorders and migraine caused by streptomycin, neuropathic pain, elderly pain of shoulder, backache, arthritis and hepatitis and skin cosmetics. It is reported that chondroitin sulfate can also be effective on improving and repairing of articular cartilage, synovium, keep the lubrication between the joints cartilages and making it elastic, alleviating joint pain and inflammation. Moreover, it also has special efficacy on symptoms located in tendons, ligaments, and diaphragm.
Chondroitin sulfate is also an important component of eye tissue. It can boost the water metabolism in corneal, improve the microcirculation, protect the cornea and promote the repair function of corneal tissue. It can also form a protective form in the corneal surface to prevent water evaporation which can effectively relieve visual fatigue and symptoms of dry eye; In additions to its anti-bacterial and anti-inflammatory effect, taurine can also participates in a lot of physiological activities in eye tissue and promote metabolism, alleviate visual fatigue.

Pharmacology and toxicology：
Chondroitin sulfate is widely existed in human and animal cartilage.  Its pharmaceutical preparation mainly contains two isomers: chondroitin sulfate A and chondroitin sulfate C. The content of chondroitin sulfate is different in animal cartilage of different breeds and ages.  Its pharmacological effects performance is as follows:
Chondroitin sulfate can clear the blood lipid and lipoprotein, clear the cholesterol on blood vessels around the heart, prevent atherosclerosis and increase the turnover rate of lipids and fatty acids inside the cell.
Chondroitin sulfate can effectively prevent and treat coronary heart disease.  It has effect of anti-atherosclerosis and anti-plaque formation on experimental atherosclerosis mode.  It can increase the circulation of branches or lateral branches of atherosclerotic coronary artery, and can accelerate the healing, regeneration and repair of the myocardial necrosis or degeneration caused by experimental coronary artery atherosclerosis or embolism.
It can increase the biosynthesis of cell messenger RNA (mRNA) and deoxyribonucleic acid (DNA) as well as having a role in the promotion of cell metabolism.
It has a low anticoagulant activity.  Chondroitin sulfate has a mild anti-clotting effect.  Every mg of chondroitin sulfate A can yield equivalent anti-clotting effect to 0.45U heparin.  Such anticoagulant activity is not relied on the effect of antithrombin III and it can take effect through the fibrinogen system instead.
Chondroitin sulfate also has an anti-inflammatory effect, and can accelerate the healing of wound healing and have anti-tumor effects.