What is the Denosumab (usan)?

Denosumab (usan) is , while it's Molecular Formula is C6404H9912N1724O2004S50. Prevention and treatment of all forms of osteoporosis or bone loss.

What is the CAS number for Denosumab (usan)?

The CAS number of Denosumab (usan) is 615258-40-7.

What is Denosumab (usan) (615258-40-7) used for?

Denosumab, which was approved in the United States in 2010, is a fullyhuman sequence IgG2 monoclonal antibody that inhibits bone resorptionby blocking the activity of receptor activator of nuclear factor-κB ligand(RANKL). RANKL is a TNF family protein that is expressed in bothsecreted and cell surface forms by a variety of bone marrow cell typesandmediates bone resorption through its receptor (RANK),which is foundon osteoclasts and osteoclast precursors . Denosumab was discoveredusing XenomouseTM transgenic mice comprising human immunoglobulingenes. The antibody is approved for treatment of postmenopausalwomen with osteoporosis at high risk for fracture, and for the prevention ofskeletal-related events in patients with bone metastases from solid tumors.Denosumab competes directly with bisphosphonates such as alendronicacid in postmenopausal osteoporosis and with zoledronic acid in both ofthese indications. It has been shown to have comparable efficacy and safetyto bisphosphonates with some tolerability and patient acceptability advantages.