1261289-04-6

Product Details:

CasNo： 1261289-04-6

Molecular Formula： C16H11Cl2N3O2S

Appearance： White to off-white Powder

Packing： Bottle

Throughput： 10KG/Month

Purity： 99%

O‑304 is an investigational, orally‑available pan‑AMPK activator, not yet approved for clinical marketing. All indications below are under pre‑clinical or Phase II‑a clinical research only.

1. Type 2 Diabetes Mellitus (T2DM)：Improve glucose homeostasis, reduce insulin resistance, improve peripheral microvascular perfusion; completed Phase II‑a proof‑of‑concept clinical trialPMC.
2. Metabolic syndrome & Obesity：Increase energy expenditure, reduce body fat mass, ameliorate fatty‑liver (MASLD) in pre‑clinical models.
3. Diabetic‑related cardiovascular complications：Lower blood pressure, improve cardiac function and micro‑circulation in diabetes settingPMC.
4. Pre‑clinical research also covers renal protection, metabolic aging, neuropathic pain research (no human clinical data available).

Product Name: O‑304 (ATX‑304)

CAS‑No: 1261289‑04‑6

Molecular Formula: C₁₆H₁₁Cl₂N₃O₂S

Molecular Weight: 380.25

Category: Investigational small‑molecule pan‑AMPK activator, research‑use compound only

Mechanism of Action: Inhibits dephosphorylation of p‑AMPK (Thr‑172 site), maintains AMPK in phosphorylated‑active status; triggers downstream glucose uptake, fatty‑acid oxidation, mitochondrial biogenesis, exercise‑mimetic metabolic effects.

Appearance: Off‑white to pale‑yellow crystalline solid powder

Purity: ≥98% (HPLC)

Solubility: Soluble in DMSO; sparingly soluble in ethanol; practically insoluble in water

Storage: Store at ‑20 °C, sealed, protected from light and moisture. Avoid repeated freeze‑thaw cycles.

Notice: For laboratory research use only. Not for human or veterinary therapeutic administration. Not an approved commercial API.