1997387-43-5

Product Details:

CasNo： 1997387-43-5

Molecular Formula： C19H27N3O2S

Appearance： White to off-white Powder

Packing： Aluminium bag

Throughput： 300KG/Month

Purity： 99%

PZM21 is a landmark G protein-biased μ-opioid receptor (μOR) agonist discovered by structure-based virtual screening and rational lead optimization. Distinct from classic morphinan opioids, it selectively triggers Gᵢ protein signaling while showing minimal β‑arrestin‑2 recruitment, which decouples analgesic efficacy from many classic opioid adverse effects.

It exhibits high binding affinity and excellent selectivity for μOR over δOR, κOR and a broad panel of other GPCR targets. In preclinical studies, PZM21 delivers robust pain relief at equianalgesic doses with greatly reduced risks of respiratory depression, reward/reinforcing effects and constipation compared with morphine.

As a well-established tool compound in GPCR pharmacology, PZM21 serves as the parent scaffold for next-generation biased μOR agonists including FH210 and other analogues for safer analgesic discovery.

Key Features

• Potent, Gᵢ-biased μOR agonist with low β‑arrestin‑2 recruitment
• Non-morphinan novel scaffold, discovered via computational structure docking
• Superior μOR selectivity against δ, κ opioid receptors and off-target GPCRs
• Important starting material & reference probe for biased opioid research

Product Specifications

• Chemical Name: 1-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea
• Molecular Formula: C₁₉H₂₉N₃O₂S
• Molecular Weight: 361.51
• Purity: ≥98% (HPLC)
• Appearance: White to off-white solid
• Solubility: Soluble in DMSO, DMF
• Storage: Store at -20°C, protected from light and moisture
• Notice: FOR RESEARCH USE ONLY. NOT FOR HUMAN USE.

Application

• GPCR pharmacological research & μOR biased signaling mechanism study
• Lead scaffold synthesis of novel low-side-effect analgesic candidates
• Synthetic precursor for FH210 and other PZM21-derived μOR ligands
• Positive reference compound for opioid receptor functional assay

Disclaimer

This product is exclusively for laboratory research. It is not approved for clinical, diagnostic or therapeutic applications.