11011-38-4
- Product Name：Ascomycin
- Molecular Formula：C43H69NO12
- Purity：99%
- Molecular Weight：792.01
Product Details:
CasNo： 11011-38-4
Molecular Formula： C43H69NO12
Appearance： White crystalline solid
Delivery Time： 2 weeks after order
Throughput： 100KG/Month
Purity： 99%
Synonyms: ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS; ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS; FR-900520; FK-520; IMMUNOMYCIN; AAG; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Boiling point: 868.3±75.0 °C at 760 mmHg
Density: 1.2±0.1 g/cm3
Solubility: Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming)
Flash point: 478.9±37.1 °C
Vapor pressure: 0.0±0.6 mmHg at 25°C
Refractive index: 1.546
Description:
This antifungal antibiotic also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.
Uses:
An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
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