1639324-58-5
- Product Name：Inclisiran sodium
- Molecular Formula：C529H707F12N176O316P43S6.xNa
- Purity：99%
- Molecular Weight：16339
Product Details:
CasNo： 1639324-58-5
Molecular Formula： C529H707F12N176O316P43S6.xNa
Appearance： White to light yellow solid
Packing： Bottle
Throughput： 1KG/Month
Purity： 99%
Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD).
Inclisiran sodium (50-200 nM; 48 h) can significantly inhibit ox-LDL-induced cell death and cytotoxicity in HUVECs, and downregulate the mRNA and protein expression of pyroptosis-related factors.
Inclisiran sodium (50-200 nM; 48 h) can inhibit ox-LDL-induced foam cell formation in Raw264.7 macrophages by activating the PPARγ pathway.
Inclisiran sodium (1-10 mg/kg; intraperitoneal injection; 20 weeks) can inhibit the development of atherosclerosis and the expression of pyroptosis-related factors in high-fat diet-induced atherosclerotic ApoE-/- mice.
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