53123-88-9

Product Details:

CasNo： 53123-88-9

Molecular Formula： C51H79NO13

Appearance： White to yellow solid

Throughput： 100KG/Month

Purity： 99%

Synonyms: 23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE; RAPA; RAPAMUNE

Density: 1.2±0.1 g/cm3
Boiling point: 973.0±75.0 °C at 760 mmHg
Flash point: 542.3±37.1 °C
Vapor pressure: 0.0±0.6 mmHg at 25°C
Refractive index: 1.551

Alpha: D25 -58.2° (methanol)

Pka: 10.40±0.70

Water Solubility: Soluble in DMSO at 50mg/ml or methanol at 25mg/ml Soluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.

Sensitive: Moisture Sensitive/Light Sensitive/Hygroscopic

Stability: Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months

Description:

Rapamycin (also known as Sirolimus is macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus isolated from soil samples from Easter Island. Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin has antirejection properties without the side effects associated with other antirejection agents. Rapamycin binds to a specific protein, Target of Rapamycin (TOR). TOR is serine/threonine kinase. TOR (mTOR) forms two major complexes: mTORC1,and mTORC2. The mTORC1 consists of mTOR, Raptor, mLST8, FKBP38, PRAS40, and Deptor, and through specific binding of rapamycin to FKBP12, rapamycin inhibits the activity of mTORC1 leading to a decrease in protein synthesis, increased autophagy and inhibition of cell growth.

Indications and Usage:
Rapamycin is a new form of immunosuppressive agent with good curative effects, low toxicity, and no nephrotoxicity. It can be used to maintain the immunity of transplant organs (especially in kidney transplants) to alleviate immunological rejections after organ transplant surgeries. The latest research has shown that Rapamycin can also be used to treat Alzheimer’s. When used on afflicted lab rats, it had a memory-restoring effect. Rapamycin oral tablets can be taken with grapefruit juice to treat melanoma (a type of benign tumor common among Western populations), dramatically increase other chemotherapy drugs’ anticancer effects, and extend patient survival. Rapamycin is a mammalian target of rapamycin (mTOR) targeting inhibitor, which can treat tumors that are related to this pathway including kidney cancer, lymphoma, lung cancer, liver cancer, breast cancer, neuroendocrine carcinoma, gastric cancer, etc. Its curative effects are especially strong for the rare diseases LAM (lymphangiomyomatosis) and TSC (tuberous sclerosis).