22573-93-9

Product Details:

CasNo： 22573-93-9

Molecular Formula： C26H56N10

Appearance： White to faintly beige powder

Delivery Time： 2 weeks after order

Throughput： 1000KG/Month

Purity： 99%

Alexidine dihydrochloride is a cationic bis(biguanide) compound with versatile biological activities, widely used in research on antimicrobial, anticancer, and metabolic regulation fields. Below is a comprehensive product introduction covering its core information, properties, applications, and handling guidelines.

1. Mechanism of Action

• Antimicrobial Activity: As a cationic bis(biguanide), it binds to microbial cell wall components (lipopolysaccharide, lipoteichoic acid), disrupting membrane integrity and inhibiting microbial activation, exerting broad-spectrum antibacterial and antifungal effects. It also shows potent antibiofilm activity against drug-resistant fungi (e.g., Candida, Aspergillus) at low concentrations (1.5–6 μg/mL).
• PTPMT1 Inhibition: Selectively inhibits mitochondrial protein tyrosine phosphatase 1 (PTPMT1) with an in vitro IC₅₀ of 1.08 μM. This inhibition stimulates insulin secretion in pancreatic β-cells and induces mitochondrial-mediated apoptosis in cancer cells (e.g., FaDu), supporting its potential in type 2 diabetes treatment and anticancer therapy.
• Stem Cell Preservation: Preserves functional hematopoietic stem cells ex vivo, indicating applications in regenerative medicine research.

2. Key Applications

1. Antimicrobial Research: Development of antibiofilm agents and treatments for drug-resistant microbial infections.
2. Oncology: Investigation as an apoptosis-promoting anticancer agent targeting mitochondrial pathways.
3. Metabolic Disorders: Research on improving insulin secretion for type 2 diabetes management.
4. Stem Cell Biology: Ex vivo preservation of hematopoietic stem cells.
5. Analytical Standards: Used as a reference standard for quantitative analysis in pharmaceutical and biological research.

3. Safety & Handling

• Hazard Statements: May cause skin/eye irritation; harmful if swallowed or inhaled.
• Precautionary Measures: Use in a fume hood with PPE (gloves, goggles, lab coat). Avoid contact with incompatible substances (strong oxidizers).
• Disposal: Dispose of waste in accordance with local regulations (as hazardous waste).
• Note: For research use only; not for human or veterinary clinical applications.

4. Packaging & Quality Control

• Packaging: Available in 10 mg, 50 mg, 100 mg, and 1 g quantities; sealed in amber glass vials to protect from light.
• Quality Assurance: Each batch undergoes strict testing, including HPLC purity, melting point, and elemental analysis, with a certificate of analysis (COA) provided.