31690-09-2

Product Details:

CasNo： 31690-09-2

Molecular Formula： C20H25N7O6

Appearance： Off-white to pale green solid

Delivery Time： 2 weeks after order

Packing： Aluminium bag

Throughput： 10000KG/Month

Purity： 99%

Levomefolic acid, also known as L-5-Methyltetrahydrofolate (L-5-MTHF), is the biologically active form of folic acid (vitamin B9). It is widely used in pharmaceuticals, nutraceuticals, and functional food industries due to its direct bioavailability without metabolic activation in the human body.

1. Key Physicochemical Properties

• Solubility: Soluble in water, slightly soluble in methanol and ethanol; insoluble in non-polar organic solvents (e.g., chloroform, hexane).
• Stability: Stable under acidic conditions; sensitive to light, heat, and oxidation. It is recommended to store in sealed, light-proof containers with inert gas protection.
• Optical Activity: Optically active (6S configuration), which is the only form that can be directly utilized by the human body.

2. Core Functions & Applications

2.1 Pharmaceutical Applications

• Folate Deficiency Treatment: Directly replenishes the active folate in the body, suitable for patients with folate deficiency (including pregnant women, the elderly, and patients with malabsorption syndromes). It avoids the metabolic barrier of traditional folic acid in people with MTHFR gene polymorphism.
• Neural Tube Defect Prevention: A first-line supplement for pregnant women during the periconceptional period, which effectively reduces the risk of fetal neural tube defects (e.g., spina bifida, anencephaly).
• Cardiovascular Health: Works with vitamin B12 to lower homocysteine levels in the blood, reducing the risk of cardiovascular and cerebrovascular diseases such as atherosclerosis and stroke.
• Support for Chemotherapy Patients: Used as an adjuvant drug in cancer chemotherapy (e.g., combined with methotrexate) to reduce side effects and improve treatment tolerance.

2.2 Nutraceutical & Functional Food Applications

• Dietary Supplements: Formulated into tablets, capsules, oral liquids, etc., targeting specific groups such as pregnant women, lactating women, and people with high homocysteine levels.
• Functional Food Fortification: Added to milk powder, cereal, health drinks, and other products to enhance the nutritional value of folate.

3. Storage & Transportation

• Storage: Seal tightly, store in a cool, dry, and light-proof environment (temperature ≤25℃, relative humidity ≤60%). Avoid contact with oxidants and strong acids/bases. The shelf life is 24 months under proper storage conditions.
• Transportation: Classified as a non-hazardous chemical. During transportation, prevent exposure to sunlight, rain, and high temperature. Avoid mixing with toxic and harmful substances.

4. Safety Information

• Toxicity: Low toxicity; the oral LD₅₀ in rats is >5000 mg/kg body weight.
• Dosage Guidelines: For general supplementation, the recommended daily dose is 0.4–1.0 mg; for pregnant women, it can be increased to 0.8–1.0 mg under medical guidance.
• Precautions: Do not take high doses for a long time without medical advice; people taking antiepileptic drugs or methotrexate should consult a doctor before use.