96702-03-3

Product Details:

CasNo： 96702-03-3

Molecular Formula： C6H10N2O2

Appearance： White to off-white Powder

Delivery Time： 2 weeks after order

Packing： Aluminium bag

Throughput： 10000KG/Month

Purity： 99%

Ectoine, chemically named (4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid, is a naturally occurring compatible solute and osmoprotectant. It is widely produced by halophilic microorganisms (e.g., Halomonas elongata) to survive extreme osmotic stress. Ectoine has gained significant attention in pharmaceuticals, cosmetics, and biotechnology due to its excellent cell-protective properties.

1. Key Physicochemical Properties

• Solubility: Highly soluble in water and polar organic solvents (e.g., methanol, ethanol); insoluble in non-polar solvents (e.g., hexane, chloroform).
• Stability: Excellent stability over a wide pH range (3.0–9.0); resistant to high temperature (stable at 121℃ for 30 min) and UV irradiation, making it suitable for various formulation processes.
• Hygroscopicity: Moderate hygroscopicity; can form a hydration shell on the cell surface to maintain water balance.

2. Core Functions & Applications

2.1 Cosmetic Industry

This is the largest application field of ectoine.

• Skin Barrier Repair: Forms a protective film on the skin surface, repairs damaged stratum corneum, and alleviates dryness, redness, and irritation caused by environmental factors (UV, pollution, harsh chemicals).
• Anti-aging & Anti-UV: Inhibits the production of reactive oxygen species (ROS) induced by UV radiation, reduces photoaging damage such as wrinkles and pigmentation.
• Sensitive Skin Care: Ideal for formulating products for sensitive, acne-prone, or post-procedure skin (e.g., after laser treatment) due to its mild, non-irritating properties.
• Common Formulations: Serums, moisturizers, sunscreens, after-sun repair products, and baby skincare products.

2.2 Pharmaceutical Applications

• Topical Dermatological Drugs: Used in ointments or creams for treating atopic dermatitis, eczema, and contact dermatitis; relieves inflammation and itching by protecting skin cells.
• Ophthalmic Products: Added to eye drops to protect corneal epithelial cells, alleviate dry eye syndrome, and reduce irritation caused by preservatives in eye care products.
• Respiratory Health: Research shows that ectoine can reduce airway inflammation caused by allergens or pollutants, with potential applications in drugs for allergic rhinitis and asthma.

2.3 Biotechnology & Agriculture

• Bioprocessing: Used as a stabilizer for enzymes, antibodies, and vaccines during storage and transportation; maintains the biological activity of biomolecules under harsh conditions (e.g., freeze-thaw cycles, high temperature).
• Agriculture: Applied as a plant growth regulator; enhances crop tolerance to drought, salinity, and extreme temperatures, improving yield and quality in harsh environments.

3. Quality Control Standards

4. Production Methods

1. Microbial Fermentation: The mainstream industrial production method. Using halophilic bacteria (e.g., Halomonas elongata) as strains, ectoine is synthesized through fermentation in high-salt culture medium, followed by separation, purification, and crystallization. This method is eco-friendly, cost-effective, and suitable for large-scale production.
2. Chemical Synthesis: Laboratory-scale synthesis is achievable via multi-step reactions, but it is rarely used industrially due to complex processes, low yields, and high costs.

5. Storage & Transportation

• Storage: Seal tightly in a cool, dry, and light-proof container; store at 2–8℃ for long-term preservation. Avoid contact with oxidants and strong acids/bases. Shelf life is 24 months under recommended storage conditions.
• Transportation: Classified as a non-hazardous chemical. Prevent exposure to sunlight, rain, and high temperature during transportation. Avoid mixing with toxic and harmful substances.

6. Safety Information

• Toxicity: Extremely low toxicity; oral LD₅₀ in rats is >5000 mg/kg body weight. No skin irritation or sensitization has been reported in clinical tests.
• Precautions: For industrial production, operators should wear protective gloves and goggles to avoid direct contact with eyes and skin. For cosmetic and pharmaceutical formulations, follow relevant regulatory dosage limits.