2001-95-8

Product Details:

CasNo： 2001-95-8

Molecular Formula： C54H90N6O18

Appearance： White to off-white Powder

Delivery Time： 2 weeks after order

Packing： Aluminium bag

Throughput： 10000KG/Month

Purity： 99%

Valinomycin (CAS: 2001-95-8) is a cyclic depsipeptide ionophore antibiotic naturally produced by Streptomyces fulvissimus and other Streptomyces species. It is widely used in biochemistry, pharmaceutical R&D, and analytical applications due to its exceptional potassium ion (K⁺) selectivity. Below is a comprehensive product overview:

1. Mechanism of Action

Valinomycin acts as a highly K⁺-selective ionophore. Its cyclic structure forms a hydrophobic outer surface and a polar inner cavity, which specifically encapsulates K⁺ via 6 carbonyl oxygens (coordination number 8 when bound to water molecules). This complex enables K⁺ to diffuse across lipid bilayers down the electrochemical gradient, disrupting cellular ion homeostasis and membrane potential. The K⁺-valinomycin stability constant (10⁶) is 10⁵ times higher than that of Na⁺, ensuring strict K⁺ selectivity.

2. Key Biological Activities & Applications

• Biochemical Research: Gold-standard tool for studying K⁺ transport, membrane potential, and mitochondrial function; used in patch-clamp and ion-selective electrode (ISE) development.
• Antimicrobial & Antiparasitic: Potent against Gram-positive bacteria, Mycobacterium tuberculosis, nematodes, and insects; disrupts microbial ion balance to induce cell death.
• Biomedical R&D: Induces apoptosis in cancer cells; inhibits ATP synthesis; investigated for antiviral activity against coronaviruses, flaviviruses, and bunyaviruses.
• Analytical Chemistry: Critical component in K⁺-specific ISEs for clinical and environmental testing.

3. Safety & Handling

• Toxicity: Potent cytotoxicity; avoid inhalation, skin contact, or ingestion.
• Storage: Store at 2–8 °C in a dry, well-ventilated area; keep containers tightly closed.
• Regulatory: Handled as a research reagent; not approved for human or veterinary therapeutic use.

4. Packaging & Supply

• Standard packaging: 10 mg, 100 mg, 1 g, 10 g, 50 g, and custom batches.
• Supporting documents: COA, MSDS, and structural confirmation (e.g., NMR, HPLC) available upon request.