52665-69-7

Product Details:

CasNo： 52665-69-7

Molecular Formula： C29H37N3O6

Appearance： White to light yellow to light orange Powder

Delivery Time： 2 weeks after order

Packing： Aluminium bag

Throughput： 10000KG/Month

Purity： 99%

Calcimycin (CAS: 52665-69-7; Synonyms: A23187, Calcium Ionophore, Antibiotic A23187) is a carboxylic acid antibiotic and divalent cation ionophore naturally isolated from the fermentation broth of Streptomyces chartreusensis. It is widely applied in biochemistry, cell biology, and pharmaceutical R&D for its unique ability to transport Ca²⁺, Mg²⁺, and Mn²⁺ across biological membranes. Below is a comprehensive product overview:

1. Mechanism of Action

Calcimycin is a mobile divalent cation ionophore with a distinct selectivity order: Mn²⁺ > Ca²⁺ ≈ Mg²⁺ > Sr²⁺ > Ba²⁺. Its structure forms a hydrophobic exterior and a polar cavity that coordinates divalent cations via carbonyl and hydroxyl groups. This cation - ionophore complex diffuses across lipid bilayers, equalizing intracellular and extracellular cation concentrations. It also uncouples mitochondrial oxidative phosphorylation and inhibits ATPase activity, disrupting cellular energy metabolism and triggering Ca²⁺ - dependent apoptosis.

2. Key Biological Activities & Applications

• Cell Biology Research: Gold - standard tool for manipulating intracellular Ca²⁺ levels to study Ca²⁺ - mediated signaling, autophagy, and apoptosis; used in calibrating fluorescent Ca²⁺/Mg²⁺ indicators and patch - clamp experiments.
• Antimicrobial Activity: Inhibits Gram - positive bacteria (e.g., Staphylococcus aureus) and some fungi; induces mycobacterial killing via Ca²⁺ - regulated autophagy.
• Biomedical R&D: Induces oocyte activation for assisted reproduction (ICSI); triggers ROS production and platelet fragmentation; investigated for anticancer (apoptosis induction) and anti - parasitic activity.
• Analytical Chemistry: Used in ion - selective electrode development for divalent cation detection.

3. Safety & Handling

• Toxicity: Cytotoxic; avoid inhalation, skin contact, or ingestion. It may cause eye/skin irritation and acute toxicity if exposed in large amounts.
• Storage: Store at - 20 °C in a desiccated, light - protected container; avoid repeated freeze - thaw cycles.
• Regulatory: For Research Use Only (RUO); not approved for human or veterinary therapeutic use.

4. Packaging & Documentation

• Standard packaging: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 1 g, and custom bulk quantities.
• Supporting documents: COA, MSDS, HPLC purity report, and origin certificate (fermentation - derived from Streptomyces chartreusensis) available upon request.