120279-96-1

Product Details:

CasNo： 120279-96-1

Molecular Formula： C10H16N2O4S3

Appearance： White to off-white Powder

Packing： Bottle

Throughput： 100KG/Month

Purity： 99%

Product Description

Dorzolamide hydrochloride is a potent, topical carbonic anhydrase isoenzyme II (CA‑II) inhibitor. By inhibiting CA‑II within the ciliary processes of the eye, it reduces bicarbonate‑driven aqueous humor secretion, thereby lowering elevated intraocular pressure (IOP)National D....

Supplied as research‑grade solid powder, typical purity ≥98 %. For in‑vitro and pre‑clinical laboratory research only. Not for human clinical administration. The finished approved pharmaceutical product is formulated as ophthalmic eye‑drop solution for topical ocular useDailyMed.

Mechanistically, dorzolamide suppresses aqueous humour production without pupil constriction. It can be applied as monotherapy or combined with beta‑blocking agents for additive intraocular‑pressure‑lowering effects in ophthalmology research modelsNational D....

Approved Clinical Indications

Note: These apply to finished ophthalmic drug product, not research‑grade powder material.

1. Elevated intraocular pressure associated with open‑angle glaucoma（开角型青光眼伴随眼压升高）
2. Ocular hypertension（高眼压症）
3. Pseudo‑exfoliative glaucoma（剥脱性青光眼）

• Usage: Monotherapy for patients intolerant / unresponsive to beta‑blockers; or adjunct therapy combined with topical beta‑blockersNational D....

Pre‑clinical Research‑Only Indications

1. Carbonic anhydrase enzyme pharmacology & inhibitor screening
2. Ocular hypertension and open‑angle glaucoma animal‑model pharmacological evaluation
3. Intraocular‑pressure‑lowering compound combination‑effect investigation
4. Ocular drug delivery / ophthalmic formulation research
5. Sulfonamide‑targeted enzyme‑inhibition mechanism study

Dorzolamide HCl (CAS:130693‑92‑2) is a selective carbonic anhydrase‑II inhibitor used clinically as eye‑drops to reduce intraocular pressure for open‑angle glaucoma and ocular hypertension. Our research‑grade powder is for laboratory pre‑clinical research only, not for human use.