Product Details:

CasNo： 107868-30-4

Molecular Formula： C20H24O2

Appearance： Colorless to Off-white powder

Packing： Bottle

Throughput： 100KG/Month

Purity： 98%

Exemestane 

Synonym: 6‑Methylenandrosta‑1,4‑diene‑3,17‑dione

CAS‑No.: 107868‑30‑4

Molecular Formula: C₂₀H₂₄O₂

Molecular Weight: 296.40 g/mol

Brand Name: Aromasin®

Pharmacological Class: Steroidal irreversible aromatase inactivatorDailyMed

Mechanism of Action

Exemestane functions as a false‑substrate‑based suicide inhibitor of aromatase (cytochrome P450 19A1), the key enzyme catalysing aromatization of androgens to estrogensDailyMed. Structurally analogous to endogenous substrate androstenedione, exemestane is metabolised by aromatase into a reactive intermediate that covalently and irreversibly occupies the enzyme‑active site, resulting in persistent enzyme inactivation. In post‑menopausal subjects, peripheral aromatase constitutes the predominant source of circulating oestrogens. Exemestane produces marked suppression of plasma oestrogen levels, while exerting minimal interference on adrenal corticosteroid or aldosterone biosynthesis at therapeutic exposuresDailyMed. It does not compete for oestrogen receptors.

Indications and Usage (Approved Clinical Label, Human Prescription)DailyMed

1. Adjuvant Endocrine Therapy for Early‑Stage Breast Cancer Adjuvant treatment for post‑menopausal women with oestrogen‑receptor‑positive (ER+) early breast cancer, following 2‑3‑years of prior tamoxifen therapy, to complete a cumulative 5‑year course of adjuvant hormonal therapy.
2. Advanced Metastatic Breast Cancer Treatment of advanced oestrogen‑dependent breast carcinoma in post‑menopausal female patients with disease progression upon prior tamoxifen‑based endocrine intervention.

Note: This active pharmaceutical ingredient is offered For Research Use Only (RUO). Not intended for human clinical formulation, compounding or direct therapeutic administration without full local regulatory authorisation.