1245732-48-2

Product Details:

CasNo： 1245732-48-2

Molecular Formula： C66H100N6O27

Appearance： Off‑white to pale yellow

Packing： Aluminium bag

Throughput： 100KG/Month

Purity： 99%

Physical‑Chemical Properties

Appearance: Off‑white to pale yellow solid / powder Sparingly soluble in water, soluble in certain organic solvents.

Mechanism of Action

Zoliflodacin is a bactericidal type‑II topoisomerase inhibitor. It targets bacterial DNA gyrase (GyrB subunit) and topoisomerase IV via a novel binding site distinct from fluoroquinolones, blocking bacterial DNA replication and cell division. It exhibits no cross‑resistance with existing antibiotic classes and retains activity against multi‑drug‑resistant Neisseria gonorrhoeae strains.

Indications

For the treatment of uncomplicated urogenital gonorrhea caused by Neisseria gonorrhoeae, in adults and paediatric patients aged 12 years and older with body weight ≥35 kg. It is administered as single‑dose oral therapy, approved by US‑FDA in December 2025 (brand name Nuzolvence)U.S. Food ....

Clinical feature: Single oral dose replaces traditional injectable ceftriaxone‑based regimen, suitable for fluoroquinolone‑resistant and cephalosporin‑resistant gonorrhea isolates.

API Quality Profile

• HPLC Purity: NLT 98.0%
• Related Substances: Total impurities ≤1.0%, individual unknown impurity ≤0.15%
• Loss on drying: ≤0.5%
• COA, HPLC, NMR, MS available for R&D and formulation development. Note: Pharmacopoeia monograph (EP/USP) not yet officially published.

Storage & Packing

Store sealed under dry, cool conditions, avoid direct light. Standard packing: 1 g, 5 g, 100 g, 1 kg / aluminium foil bag or drum for R&D & pilot manufacture.

Disclaimer

This material description is for pharmaceutical raw‑material reference only, not clinical medication guidance.