1433857-09-0

Product Details:

CasNo： 1433857-09-0

Molecular Formula： C21H25ClF3N3O4

Appearance： Off‑white to white

Packing： Aluminium bag

Throughput： 100KG/Month

Purity： 99%

Physical‑Chemical Properties

Appearance: Off‑white to pale yellow crystalline powder Very slightly soluble in water; soluble in some organic solvents. Light‑sensitive materialPMC.

Mechanism of Action

Lascufloxacin hydrochloride is a bactericidal fluoroquinolone antibiotic. It inhibits bacterial DNA gyrase and topoisomerase IV, blocking bacterial DNA replication, transcription and cell division. It shows potent activity against Gram‑positive, Gram‑negative and atypical pathogens, including macrolide‑resistant Mycoplasma pneumoniae. It retains activity against partial quinolone‑resistant isolates with incomplete cross‑resistance to older fluoroquinolones, and demonstrates good respiratory‑tract tissue penetration.

Indications

For the treatment of bacterial infections caused by susceptible strains:

• Pharyngitis, laryngitis, tonsillitis (including peritonsillitis, peritonsillar abscess)
• Acute bronchitis, community‑acquired pneumonia, secondary infection of chronic respiratory lesions
• Otitis media, sinusitis (ENT infections)

Approved in Japan (PMDA 2019) for oral once‑daily administration. Target pathogens include Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, Staphylococcus spp. and others.

API Quality Profile

• HPLC Purity: NLT 98.0%
• Total impurities: ≤1.0%, single unknown impurity ≤0.15%
• Loss on drying: ≤0.5%
• COA, HPLC, NMR, MS available for R&D and formulation development. No official EP/USP pharmacopoeia monograph published yet.

Storage & Packing

Store in tightly‑sealed container, protect from light and moisture, long‑term recommended ‑20 °C; short‑term 2‑8 °C. Available packing: 1 g, 5 g, 10 g, 100 g, 1 kg aluminium foil bag / drum for lab‑scale and pilot manufacture.

Disclaimer

This product description serves for pharmaceutical raw‑material reference only, not for clinical medication guidance.